Antidepressant Tachyphylaxis: Causes & Solutions
Introduction to Antidepressant Tachyphylaxis Antidepressant tachyphylaxis, often colloquially termed “poop-out syndrome,” represents a significant and distressing clinical phenomenon wherein an effective pharmacological treatment for Major Depressive Disorder (MDD) gradually loses its therapeutic efficacy over time, despite sustained compliance and stable dosage. This loss of response is distinct from initial non-response or relapse triggered by external […]