Introduction to Benzodiazepine Agonist Discontinuation The process of discontinuing benzodiazepine agonists represents a significant clinical challenge due to the high potential for physical dependence and the severity of associated withdrawal syndromes. Benzodiazepine agonists, widely prescribed for conditions such as generalized anxiety disorder, insomnia, and panic disorder, exert their therapeutic effects by enhancing the inhibitory neurotransmitter […]
Introduction: The Complexity of Benzodiazepine Discontinuation The clinical utility of benzodiazepine agonists (BZAs), including traditional benzodiazepines and Z-drugs, in managing acute anxiety and insomnia is well-established; however, their long-term use presents significant challenges, primarily revolving around the difficulty of safe and successful discontinuation. These agents exert their therapeutic effects by potentiating the inhibitory neurotransmitter gamma-aminobutyric […]